Run the Check disk utility at the system startup.
Run the latest eScan hotfix on the machine and check after restarting the machine by taking the updates.
Delete all the files from C:\program files\escan\FTPTEMP\ folder if present and then again try taking updates
If you get below error in the download.log file
Error getting MD5 of C:\DOCUME~1\ALLUSE~1\APPLIC~1\MICROW~1\eScanBD\Plugins\emalware.215!
Delete all the files from plugins folder i.e. from c:\program files\escan\plugins & c:\DOCUME~1\ALLUSE~1\APPLIC~1\MICROW~1\eScanBD\Plugins\ & then take update.